BRI Biopharmaceutical Research Inc. is a specialized analytical, bioanalytical and DM/PK contract research organization (CRO) servicing pharmaceutical and biotechnology companies in discovery, preclinical and clinical programs supporting IND and NDA-enabling studies.
The bioanalytical LC/MS/MS group was operating since 1999 founded by Dr. David Kwok. Over the years BRI performed hundreds of quantitative assays on small molecule drugs, metabolites and chemical biomarkers supporting Phase I to IV Clinical PK samples and DM/PK preclinical samples. Bioanalytical assay experience includes immunochemical ELISA and cell-based assays of small molecule chemical biomarkers and large molecules.
BRI has also performed hundreds of CMC studies highly experienced in analytical chemistry and USP monograph assays including HPLC, GC/Headspace assay and GC/MS assay of drug substances, impurities, degradation products and clinical products including parenteral liquids, capsules, tablets, and semi-solid topical formulations.
BRIVAL™ is our in vitro drug metabolism group co-founded and operated by Dr. Albert P Li and Ms. Clara Faan, featuring a full suite of in vitro metabolism studies based on human and animal hepatocytes, microsomes, S9 fractions and recombinant CYP450 and Phase II enzymes.
Oncograph™ featuring a unique patient-derived orthotopic sub-renal capsule Xenograft efficacy mouse models is founded by a group of world experts in the area of cancer modeling, anti-cancer drug evaluation and personalized cancer therapy. Over 130 transplantable patient-derived tumor Xenografts of various cancers including prostate, ovary, lung, pancreas, skin and kidney with over 90% engraftment has been developed supporting new drug candidate development and translational personalized oncology drug therapy selection for patients.
Our vivarium also provides in vivo rodent DM/PK and in vivo toxicology screening based on a variety of dose formulations and routes of administrations. The facility is certified under the Canadian Council of Animal Care (CCAC) and Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC).